Description
Interleukin 3 is also known as IL-3, is a protein that in humans is encoded by the IL3 gene.
Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system.
It acts by binding to the interleukin-3 receptor.
The IL-3 receptor is a heterodimer of the IL-3 specific α-chain and the common β-chain, βc, which is also used by GM-CSF and IL-5.
[3] Binding of IL-3 can also involve substitution of the βc by a βIL-3-chain that appears to be specific for IL-3.
Binding of IL-3 to its cognate receptor(s) induces activation of Jak2, phosphorylation of multiple Stats, and the PI3K/Akt pathway.
IL-3 may play an important role in the development of airway inflammation associated with asthma.
The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated.
The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF